Figure 6.

Dynamics of inflammatory phenotype in the Scnn1b -Tg mouse as represented by cytokine production GO node. (a) The children nodes of the "Cytokine Production" node of the Gene Ontology biological process were arranged as clusters of connected entities (boxes) according to the hierarchy of GO terms, and visualized in Cytoscape. Each box represents a GO term and associated genes as defined by the GO annotation. Only functional GO terms containing at least 3 annotated genes were included. (b) Activation of the "Cytokine Production" GO node in Scnn1b-Tg mice in the two tissues studied across time. Red indicates the nodes within this GO cluster that are significantly enriched with annotated genes up-regulated in the Scnn1b-Tg mice with the intensity of the color reflecting the significance of the collective shifts of annotated genes to up-regulation (darker = more significant), as reflected by GSEA FDR values. Green represents collective shifts of annotated genes to down-regulation in the Scnn1b-Tg mice compared to WT as determined by GSEA.