Table 2.
Developmentally regulated genes in whole lung from Scnn1b -Tg mice
| Gene Name | Fold change: PND 3 vs 0 | Gene Name | Fold change: PND 10 vs 3 | Gene Name | Fold change: PND 42 vs 10 | |||
|---|---|---|---|---|---|---|---|---|
| Scnn1b -Tg | WT | Scnn1b -Tg | WT | Scnn1b -Tg | WT | |||
| UP-REGULATED | ||||||||
| Vaultrc5* | 27.7 | 28.4 | Clca3 | 12.0 | 71.4 | Gm10800 | 67.8 | 17.6 |
| Gm22866* | 26.8 | 24.4 | Mmp12 | 11.5 | 1.9 | Gm10722 | 43.9 | 25.8 |
| Snora16a* | 22.0 | 20.3 | Tff2 | 7.9 | 8.0 | Snord116* | 19.6 | 26.2 |
| Rnu3a* | 16.6 | 18.4 | C7 | 7.4 | 5.4 | Lrat | 14.7 | 14.8 |
| Rny1* | 15.6 | 13.1 | Crabp1 | 5.7 | 8.9 | Nr1d1 | 14.4 | 13.8 |
| Rnu3b1* | 14.7 | 15.7 | Chi3l3 | 5.2 | 10.1 | Cfd | 14.4 | 13.9 |
| n-R5s25* | 13.6 | 12.4 | Chi3l4 | 4.6 | 13.0 | C4b | 13.8 | 13.2 |
| Gm23927* | 13.5 | 10.0 | H2-Aa | 4.6 | 2.6 | Chi3l3 | 12.2 | 1.4 |
| Snord22* | 13.4 | 13.7 | H2-Ab1 | 4.3 | 2.8 | Car3 | 11.9 | 10.6 |
| Gm23444 | 13.3 | 13.9 | Ltbp2 | 3.9 | 6.8 | Prelp | 11.6 | 11.6 |
| Gm26493 | 13.2 | 17.3 | 4833424O15Rik | 3.8 | 2.7 | Clca3 | 11.6 | -10.9 |
| Snora69* | 11.9 | 13.3 | Cd74 | 3.7 | 2.3 | Inmt | 10.8 | 17.8 |
| Snora23* | 10.5 | 12.4 | H2-Eb1 | 3.7 | 2.6 | Chi3l4 | 10.5 | -8.9 |
| Snord35b* | 9.6 | 7.9 | Aard | 3.6 | 1.9 | Cxcl14 | 10.2 | 8.0 |
| Snora34* | 9.3 | 9.6 | Cdkn2c | 3.4 | 3.3 | Speer8-ps1 | 10.2 | 8.7 |
| DOWN-REGULATED | ||||||||
| Meg3* | -34.3 | -32.1 | Gm26493* | -16.0 | -12.3 | Egfem1 | -18.0 | -24.0 |
| C530030P08Rik | -19.0 | -10.3 | Gm24616* | -12.2 | -8.8 | H19* | -13.9 | -5.5 |
| Mir145* | -11.9 | -6.2 | Snora69* | -9.6 | -9.8 | Slc27a6 | -12.6 | -12.7 |
| 6720401G13Rik | -11.7 | -7.9 | Snora23* | -9.4 | -5.5 | Tnc | -10.0 | -25.1 |
| Malat1* | -9.7 | -8.8 | Snora34* | -6.0 | -5.1 | Capn6 | -9.8 | -7.6 |
| Gm7265 | -9.5 | -4.5 | Gm10722 | -4.7 | -1.7 | Agt | -9.3 | -14.8 |
| Wnk1 | -9.0 | -5.8 | S100a14 | -3.9 | -3.4 | Prss35 | -9.2 | -18.4 |
| Mir23b* | -8.6 | -5.1 | Gm22806* | -3.6 | -3.1 | Pbk | -8.8 | -3.7 |
| Cox20 | -7.9 | -5.5 | Rnu1b1* | -3.6 | -2.4 | Stfa2l1 | -8.7 | -9.5 |
| Nfat5 | -7.6 | -5.6 | Cldn4 | -3.5 | -4.5 | Hist1h2ab | -8.6 | -7.3 |
| Gm25831* | -7.2 | -2.6 | Agtr2 | -3.2 | -3.6 | Nuf2 | -8.3 | -5.6 |
| Leng8 | -7.1 | -5.2 | Igf2 | -3.1 | -4.0 | Ccnb2 | -7.9 | -5.6 |
| Fbxl7 | -5.9 | -3.4 | Upk3a | -3.1 | -2.4 | Ccna2 | -7.8 | -9.9 |
| B930095G15Rik | -5.7 | -3.7 | Cst8 | -2.8 | -2.3 | Spon2 | -7.6 | -12.7 |
| Srrm2 | -5.7 | -4.2 | Liph | -2.7 | -1.9 | Vcan | -7.5 | -14.4 |
Top 15 developmentally up- and down-regulated genes from whole lung of Scnn1b-Tg mice between three separate age intervals. The fold-changes for these top 15 genes are shown for both Scnn1b-Tg and the WT mice.
* Non-coding RNA species.