Table 5.
Differentially regulated Gene Ontology groups from whole lung between WT and Scnn1b- Tg mice
| PND 0 | PND 3 | PND 10 | PND 42 |
|---|---|---|---|
| UP-REGULATED | |||
| GO:0031424 | NONE* | GO:0006953 | GO:0006954 |
| Keratinization | Acute-phase response | Inflammatory response | |
| GO:0035195 | GO:0002526 | GO:0050715 | |
| Gene silencing by miRNA | Acute inflammatory response | Positive regulation of cytokine secretion | |
| GO:0090505 | GO:0050707 | GO:0001816 | |
| Epiboly involved in wound healing | Regulation of cytokine secretion | Cytokine production | |
| GO:0090504 | GO:0003341 | GO:0050663 | |
| Epiboly | Cilium movement | Cytokine secretion | |
| GO:0035194 | GO:0050715 | GO:0002444 | |
| Posttranscriptional gene silencing by RNA | Positive regulation of cytokine secretion | Myeloid leukocyte mediated immunity | |
| GO:0044319 | GO:0006954 | GO:0002274 | |
| Wound healing, spreading of cells | Inflammatory response | Myeloid leukocyte activation | |
| GO:0035278 | GO:0045087 | GO:0050707 | |
| Negative regulation of translation involved in gene silencing by miRNA | Innate immune response | Regulation of cytokine secretion | |
| GO:0045974 | GO:0032640 | GO:0043299 | |
| Regulation of translation, ncRNA-mediated | Tumor necrosis factor production | Leukocyte degranulation | |
| GO:0035313 | GO:0002886 | GO:0006955 | |
| Wound healing, spreading of epidermal cells | Regulation of myeloid leukocyte mediated immunity | Immune response | |
| GO:0040033 | GO:0044782 | GO:0050729 | |
| Negative regulation of translation, ncRNA-mediated | Cilium organization | Positive regulation of inflammatory response | |
| DOWN-REGULATED | |||
| GO:0048002 | GO:0007059 | GO:0043931 | NONE* |
| Antigen processing and presentation of peptide antigen | Chromosome segregation | Ossification involved in bone maturation | |
| GO:0009410 | GO:0007067 | GO:0061298 | |
| Response to xenobiotic stimulus | Mitosis | Retina vasculature development in camera-type eye | |
| GO:0006805 | GO:0000280 | GO:0060039 | |
| Xenobiotic metabolic process | Nuclear division | Pericardium development | |
| GO:0002495 | GO:0048285 | GO:0070977 | |
| Antigen processing and presentation of peptide antigen via MHC class II | Organelle fission | Bone maturation | |
| GO:0071466 | GO:0051301 | GO:0002067 | |
| Cellular response to xenobiotic stimulus | Cell division | Glandular epithelial cell differentiation | |
| GO:0002367 | GO:0071103 | GO:0030198 | |
| Cytokine production involved in immune response | DNA conformation change | Extracellular matrix organization | |
| GO:0002374 | GO:0006260 | GO:0043062 | |
| Cytokine secretion involved in immune response | DNA replication | Extracellular structure organization | |
| GO:0002478 | GO:0006261 | GO:0097435 | |
| Antigen processing and presentation of exogenous peptide antigen | DNA-dependent DNA replication | Fibril organization | |
| GO:0034381 | GO:0051297 | GO:0007044 | |
| Plasma lipoprotein particle clearance | Centrosome organization | Cell-substrate junction assembly | |
| GO:0097006 | GO:0000278 | GO:0050919 | |
| Regulation of plasma lipoprotein particle levels | Mitotic cell cycle | Negative chemotaxis | |
Top ten differentially up- and down-regulated Gene Ontology groups from whole lung between WT and Scnn1b-Tg mice at the four developmental stages. Groups are only listed if FDR <0.1.
NONE indicates that no groups reached the significance threshold (FDR<0.1).