Table IV.

Frequency of alleles and genotypes the CCND1 gene variant c.723G>A (rs9344) in differentiated thyroid carcinoma patients with regard to tumor-node-metastasis staging.

	Staging
Factor	T1		T1a		T1b		T2		T3		T4		Tx
Number of patients, n (%)	12 (2.46)		180 (36.97)		41 (8.42)		93 (19.10)		66 (13.55)		68 (13.96)		27 (5.54)
c.723G>A
Allele	G	A	G	A	G	A	G	A	G	A	G	A	G	A
Frequency, %	70.8	29.2	46.4	53.6	41.5	58.5	46.2	53.8	50.0	50.0	53.7	46.3	37.0	63.0
c.723A positivity
OR	0.226		0.989		1.108		1.160		1.172		0.837		1.829
CI	0.070–0.725		0.641–1.524		0.513–2.396		0.672–2.002		0.624–2.204		0.466–1.501		0.619–5.402
P-value	0.007		0.959		0.793		0.595		0.621		0.550		0.268
c.669C>T
Allele	C	T	C	T	C	T	C	T	C	T	C	T	C	T
Frequency, %	95.8	4.2	96.1	3.9	98.8	1.2	96.8	3.2	97.5	2.5	2.2	97.8	96.3	3.7
c.669T positivity
OR	1.398		1.534		0.359		1.063		0.695		0.670		1.234
CI	0.174–11.206		0.730–3.222		0.048–2.709		0.422–2.680		0.205–2.359		0.198–2.273		0.278–5.477
P-value	0.751		0.256		0.300		0.897		0.557		0.518		0.782

T, tumor; OR, odds ratio; CI, confidence interval.