Table I.
Clinical and pathological features of previously reported cases of adrenocortical carcinosarcoma.
| Ref. | Author, year | Age, years/gender | Clinical presentation | Endocrine dysfunction | Location | Size/weight | Sarcomatous component | Immunostaining results | Total number of antibodies | POS | |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Caricinomatous | Sarcomatous | ||||||||||
| 14 | Okazumi et al, 1987 | 46/M | Abdominal distention | No | R | 14 cm, 880 g | Spindle cell | NA | NA | NA | 6 months |
| 15 | Collina et al, 1989 | 68/F | Abdominal discomfort | No | L | 11 cm NA |
Spindle cell | Low molecular weight CK, Vim | Low molecular weight CK, Vim | 7 | 6 months |
| 9 | Decorato et al, 1990 | 42/F | Abdominal pain | No | L | 19 cm, 1400 g | Rhabdo-myosarcoma | - | muscle specific actin | 5 | 7 months |
| 10 | Fischler et al, 1992 | 29/F | ↓ Weight, virilization | Yes | L | 12.5 cm, 610 g | Rhabdo-myosarcoma | Vim, | Vim, HHF and desmin | 5 | 8 months |
| 13 | Barksdale et al, 1993 | 79/F | Hypertension | Yes | R | 9 cm, 199 g | Osteosarcoma, chondrosarcoma | Vim | Vim | 5 | NA |
| 16 | Lee et al, 1997 | 61/M | Flank pain | Yes | R | 12 cm NA |
Spindle cell | CK, focal NSE | CK, Vim | 10 | 2 days |
| 17 | Sturm et al, 2008 | 31/M | Abdominal pain | No | L | 12 cm, 620 g | Spindle cell | CD56, Vim, focal desmin, CK AE1/AE3, α-inhibin, Syn | CD56, Vim, focal desmin, HHF35 | 17 | 3 months |
| 18 | Coli et al, 2010 | 75/F | Abdominal pain | No | L | 15 cm NA |
Spindle cell | CK (MNF-16), Vim, S-100, melan-A, focal HMB-45 | Vim, SMA, desmin, caldesmon, myogenin | 20 | 12 months |
| 11 | Sasaki et al, 2010 | 45/M | Abdominal pain | No | L | 17 cm, 2974 g | Rhabdo-myosarcoma | Vim, Syn, melan-A, and calretinin | Vim, Syn, melan-A, and calretinin; desmin, myogenin, myoglobin | 15 | 3 months |
| 19 | Bertolini et al, 2011 | 23/F | Fatigue, ↓ appetite, fixed mass in rectum | No | L | 14 cm NA |
Osteosarcomatous | Inhibin, calretinin | - | NA | 14 months |
| 12 | Thway et al, 2012 | 45/M | Bloating, back pain | No | L | 24 cm, 6500 g | Rhabdo-myosarcoma | Melan-A, CD56, MNF116 | Desmin, myogenin | 28 | 11 months |
| 20 | Kao et al, 2013 | 45/M | Abdominal pain, weight loss | No | R | 15 cm, 760 g | Spindle cells, undifferentiated | melan-A, inhibin, calretinin, AE1/AE3, Syn, Vim, | Vim, NSE, FLI-1; Undifferentiated: CD99 | 18 | 7 months ; alive |
| Current study | Wei et al | 63/F | Fatigue, flank pain | No | L | 8 cm NA |
Spindle cells | NSE, FLI-1 CD56, Ki-67 |
CD56, Bcl-2, NSE, Ki-67 | 11 | 1 month ; alive |
M, Male; F, Female; R, right; L, left; NA, not available; CK, cytokeratin; Vim, vimentin; -, negative, no carcinomatous or sarcomatous regions; NSE, neuron specific enolase; CD, cluster of differentiation; Syn, synaptophysin; POS, postoperative survival.