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. 2014 Nov 24;9:5403–5413. doi: 10.2147/IJN.S71623

Figure 6.

Figure 6

Lung sections of Candida albicans-infected mice.

Notes: (A) Normal lung section with HE staining (×100). (B) Lung section of C. albicans-infected mice after PAS staining and hematoxylin staining showed pulmonary interstitial edema with numerous intracellular and extracellular, round to oval, elongated, thin-walled, yeast-like, and moniliform hyphal organisms (×400). (C and D) Lung section of C. albicans-infected mice treated with PBS or null-loaded NPs after PAS staining and hematoxylin staining showed similar findings to those in untreated mice (×400). (E and F) Lung sections of C. albicans-infected mice treated with free AMB (1 mg/kg/day for 10 days, totalizing 10 mg/kg/animal) or AMB-NPs (10.0 mg/kg on the first, seventh, and 14th days, and totaling 30 mg/kg/animal, equivalent to 3.0 mg/kg/animal free AMB) after PAS staining and hematoxylin staining showed significant improvements of pulmonary interstitial edema and reduced amount of fungi (×400).

Abbreviations: AMB, amphotericin B; HE, hematoxylin and eosin; NP, nanoparticle; PAS, periodic acid-Schiff; PBS, phosphate buffer solution.