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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: Nat Commun. 2014 Nov 27;5:5567. doi: 10.1038/ncomms6567

Figure 1. MCM is sustained longer in p53−/− compared to p53+/+ mice.

Figure 1

(A) p53+/+ and p53−/− were instilled with LPS and MCM was quantified after 5, 8, and 12d of instillation. MC/mm basal lamina is reduced in p53+/+ but is sustained in p53−/− mice at 12 d following LPS instillation. (B) Lung tissue sections from p53+/+ and p53−/− mice at 12d post instillation were immunostained with antibodies to Bcl-2 and Muc5ac and with DAPI to visualize nuclei (scale bar 10 µm). (C) Percentages for Bcl-2- and Muc5ac-positive cells. (D) Cell numbers of Bcl-2- and Muc5ac-positive cells per millimeter basal lamina. Bars = group means ± standard error from the mean (n = 3–5 mice/group); * P<0.05.