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Flow chart showing the procedure utilized to identify GQC-05 as a c-MYC G-quadruplex-interactive compound with enough selectivity to use in subsequent experiments. Initially quindoline-i, NSC176327, and NSC86374 were used in an energy-minimized overlay to give rise to the pharmacophore query. This was used as described in the text to identify NSC338258 (GQC-05) as the compound to use in the subsequent exon-specific CA46 assay and ChIP analysis
