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(a). Chemical structures of SAR405838 and MI-219. (b). Affinities of SAR405838 and control compounds to human MDM2 protein, determined in a fluorescence-polarization binding assay. (c). Co-crystal structure of SAR405838/MDM2 at 2.1 Å resolution. (d). Superposition of SAR405838/MDM2 and p53 peptide/MDM2 co-crystal structures.
