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SAR405838 potently activates p53 in the SJSA-1 and HCT-116 cancer cell lines and strongly induces PUMA up-regulation and cleavage of caspase-3 and PARP in the SJSA-1 cell line but not in the HCT-116 cell line. (a–b). Analysis of dose-dependent transcriptional induction of p21, MDM2 and PUMA in both cell lines. (c–d). Analysis of dose-dependent induction of p53, p21, MDM2 and PUMA proteins and cleavage of caspase-3 and PARP in both cell lines.
