Table 1.

SAR405838 potently inhibits cell growth in cancer cell lines of diverse tumor types with wild-type p53 and displays high selectivity over cancer cell lines with mutated or deleted p53.

Cell Lines	p53 status	Cell growth Inhibition (IC50, μM)
		SAR405838	MI-219	Nutlin-3a
SJSA-1	Wild Type	0.092±0.019	1.4 ± 0.2	1.3± 0.2
RS4;11	Wild Type	0.089±0.027	1.0 ± 0.2	0.57± 0.13
LANCaP	Wild Type	0.27 ±0.03	1.1 ± 0.1	1.2 ± 0.4
HCT-116	Wild Type	0.20 ± 0.04	0.95 ± 0.05	0.86 ±0.11
HCT-116 (p53−/−)	Deletion	>20	>10	>10
SAOS-2	Deletion	>10
PC-3	Deletion	>10
SW620	Mutation	>10