Table II.
Patient data for studies included in the meta-analysis.
| A, Studies on the 91T>A polymorphism | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Age (years) | Gender (male/female) | Genotype (case/control) | |||||||
|
|
|
|
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| First author (ref.) | Case | Control | Case | Control | Total | WT Ho (TT) | Ht (TA) | VR Ho (AA) | P-valueHWE |
| Akkiz (11) | 58 (20–81)a | 58 (20–81)a | 106/22 | 106/22 | 128/128 | 77/99 | 47/27 | 4/2 | 0.919 |
| Chava (12) | 56.03 | NR | NR | NR | 50/150 | 22/81 | 28/66 | 0/3 | 0.012 |
| Chen L (13) | 49.04±12.89b | 51.66±16.12b | 45/23 | 38/37 | 68/75 | 5/10 | 27/32 | 36/33 | 0.615 |
| Chen JY (14) | 43.0±12.7b | 44.8±12.0b | 36/24 | 27/38 | 60/65 | 44/38 | 13/21 | 3/6 | 0.236 |
| Chen XB (15) | NR | NR | 178/10 | 307/17 | 188/324 | 43/38 | 79/168 | 66/118 | 0.060 |
| Ewart-Toland (16) | NR | NR | NR | NR | 344/448 | 200/279 | 121/148 | 23/21 | 0.809 |
| Ewart-Toland (16) | NR | NR | NR | NR | 1675/1038 | 1031/630 | 558/368 | 86/40 | 0.126 |
| Hienonen (17) | 68 (32–90)a | NR | 109/126 | NR | 235/94 | 122/46 | 94/43 | 19/5 | 0.208 |
| Ju (18) | 57.7±12.6b | 52.4±8.7b | 339/162 | 289/138 | 501/427 | 75/58 | 215/190 | 211/179 | 0.504 |
| Kimura (10) | NR | NR | NR | NR | 197/146 | 29/12 | 103/82 | 65/52 | 0.010 |
| Miao (19) | 58.3±9.6b | 57.5±9.5b | 460/196 | 443/213 | 656/656 | 58/91 | 290/316 | 308/249 | 0.560 |
| Sang (20) | NR | NR | NR | NR | 380/380 | 173/153 | 161/188 | 46/39 | 0.089 |
| Wang (21) | 59.8±9.7b | 58.8±7.9b | 202/94 | 202/100 | 296/302 | 34/36 | 103/111 | 159/155 | 0.026 |
| Webb (22) | 61±11.4b | 59±10.9b | 1471/1087 | 836/1844 | 2558/2680 | 1564/1667 | 880/888 | 114/125 | 0.628 |
| Zhang (23) | 57.0±11.0b | 57.4±9.6b | 171/112 | 170/113 | 283/283 | 30/42 | 111/137 | 142/104 | 0.775 |
|
| |||||||||
| B, Studies on the 169G>A polymorphism | |||||||||
|
| |||||||||
| Age (years) | Gender (male/female) | Genotype (case/control) | |||||||
|
|
|
|
|||||||
| First author (ref.) | Case | Control | Case | Control | Total | WT Ho (GG) | Ht (GA) | VR Ho (AA) | P-valueHWE |
|
| |||||||||
| Chen L (13) | 49.04±12.89b | 51.66±16.12b | 45/23 | 38/37 | 68/75 | 49/61 | 19/11 | 0/3 | 0.019 |
| Chen JY (14) | 43.0±12.7b | 44.8±12.0b | 36/24 | 27/38 | 60/65 | 39/43 | 20/20 | 1/2 | 0.859 |
| Ju (18) | 57.7±12.6b | 52.4±8.7b | 339/162 | 289/138 | 501/427 | 387/414 | 100/104 | 14/9 | 0.409 |
| Kimura (10) | NR | NR | NR | NR | 197/146 | 118/99 | 65/47 | 14/0 | 0.020 |
a
Presented as the mean (range);
b
presented as the mean ± standard deviation;
HWE, Hardy-Weinberg equilibrium; NR, not reported; Ht, heterozygote; VR Ho, variant homozygote; WT Ho, wild-type homozygote; ref., reference.