. 2014 Nov 14;9(1):219–226. doi: 10.3892/etm.2014.2070

Table III.

Summary of the ORs of the serine/threonine kinase 15 polymorphisms and risk of digestive system cancers.

A, Studies on the 91T>A polymorphism

		Dominant model			Recessive model			Ht versus WT Ho			VR versus WT Ho

Variables	N^a	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²
Total	15	1.02 (0.87–1.21)	<0.0001	68	1.19 (1.07–1.31)	0.16	26	0.97 (0.83–1.14)	0.0005	63	1.12 (0.89–1.42)	0.002	58
Ethnicity
Asian	9	0.99 (0.73–1.35)	0.0002	73	1.21 (1.08–1.36)	0.10	40	0.92 (0.69–1.22)	0.003	66	1.07 (0.74–1.55)	0.0005	71
Caucasian	5	1.04 (0.83–1.29)	0.01	68	1.08 (0.88–1.32)	0.37	6	1.02 (0.81–1.28)	0.01	68	1.08 (0.88–1.33)	0.36	9
Mixed	1	1.19 (0.89–1.58)	NA	NA	1.46 (0.79–2.68)	NA	NA	1.14 (0.84–1.54)	NA	NA	1.12 (0.99–1.28)	NA	NA
Tumor type
Esophageal	6	0.90 (0.59–1.37)	0.0001	80	1.19 (1.03–1.38)	0.24	26	0.85 (0.57–1.28)	0.0007	77	0.91 (0.55–1.53)	0.0006	77
Colorectal	6	1.03 (0.95–1.12)	0.20	31	1.24 (1.04–1.46)	0.08	49	1.01 (0.93–1.10)	0.37	8	1.18 (0.98–1.42)	0.15	39
Gastric	2	0.97 (0.68–1.37)	0.20	39	1.06 (0.83–1.35)	0.33	0	0.94 (0.65–1.36)	0.30	5	1.00 (0.69–1.45)	0.17	48
Hepatocellular	1	2.26 (1.31–3.90)	NA	NA	2.03 (0.37–11.30)	NA	NA	2.24 (1.28–3.92)	NA	NA	2.57 (0.46–14.41)	NA	NA

B, Studies on the 169G>A polymorphism

		Dominant model			Recessive model			Ht versus WT Ho			VR versus WT Ho

Variables	N^a	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²	OR (95% CI)	P-value^b	I²

Total	4	1.02 (0.82–1.28)	0.13	47	1.27 (0.25–6.49)	0.07	58	1.13 (0.90–1.43)	0.45	0	1.45 (0.29–7.22)	0.08	56
Ethnicity
Asian	3	0.98 (0.77–1.24)	0.14	49	2.04 (0.32–13.00)	0.07	62	1.07 (0.84–1.36)	0.91	0	2.29 (0.38–13.69)	0.09	59
Caucasian	1	1.69 (0.77–3.71)	NA	NA	0.15 (0.01–2.98)	NA	NA	2.15 (0.94–4.94)	NA	NA	0.18 (0.01–3.52)	NA	NA

Number of comparisons;

test for heterogeneity.

NA, not applicable; CI, confidence interval; OR, odds ratio; Ht, heterozygote; WT Ho, wild-type homozygote; VR, variant.