Figure 2.

Proposed model of coordinated transcriptional regulation of lipid catabolism via forkhead box protein class O (FOXO), transcription factor EB (TFEB), p53, and nuclear receptors. The nuclear translocation of TFEB, p53, and FOXOs is induced under conditions of metabolic stress such as nutrient depletion and growth factor deprivation. These transcription factors (TFs) regulate directly the expression of autophagy genes and the nuclear receptor and co-receptor peroxisome proliferator-activated receptor (PPAR)α and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), respectively, which control lipid catabolism.