Table 2. Highest ranked miRNAs whose expression profiles correlate most with age [11].
Positive p-values indicate correlation and negative p-values anti-correlation with age. Matched mRNAs were obtained from the published data set of Kalfalah et al. [10]. For matching of the miRNAs with proteins, the identified proteins of label-free proteome analysis were used. Matched proteins which were also identified as altered during ageing were indicated in bold.
| miRNA | correlation | p-value | Matched mRNA | Matched Protein (alteration on protein level) |
|---|---|---|---|---|
| miR-100 | 0.458 (up) | 0.086 | EIF2C2, MTOR, NOX4 | |
| miR-107 | 0.578 (up) | 0.024 | ANK1, C5ORF13, CCNYL1, FERMT2, KLF4, NFIB, PDE3B, SEMA6A, UQCC, ZC3H7B, ZNF711 | ABCF1, ADD1, AK2, ANKFY1, CAPZA2, CARM1, CTNND1, DNAJC3 (down), FERMT2, IPO9, KPNA3, PAFAH1B2, SMCHD1, SUN2 |
| miR-125b | −0.503 (down) | 0.056 | ANKH, BCL2L2, CDS2, CLDN12, CORO2A, ENPP1, GOPC, LOC645978, LRRC10B, NOS1AP, PIK3CD, PSMD7, PTAR1, RBAK, RET, RPS6KA1, SOCS4, TMBIM6, TMEM168, TRPS1, USP46, ZC3H7B | ARCN1, DPP9, ESYT1, FAM129B, MEMO1, OGFR, PIP4K2B, SRSF6, STAT3, TGOLN2 |
| miR-130b | 0.503 (up) | 0.056 | BAG5, BCAT1, BPTF, CSF1, EREG, FERMT2, FIBIN, FLJ36031, GPATCH8, HSPA8, INO80, IRF1, KIAA0319L, LMTK2, LRRTM2, MAP3K9, MED15, MLEC, NCKIPSD, NFIB, PDE5A, RAB5B, SKP1, SMOC2, SNAP25, SPG20, TNRC6B, TSPYL2, WNK1, ZBTB4, ZNF711 | CEP170, HOOK3, MAP1B, TRIM3 |
| miR-181a | −0.58 (down) | 0.023 | ANK1, ARL5A, ATP2B3, BPTF, C15ORF29, CCP110, CDH13, CDS2, CPEB4, CTTNBP2NL, DEK, FAM122B, FAM13B, FAM160A2, INO80, LIMS1, LRRC8D, LRRFIP1, MCL1, METAP1, MOSPD1, NDRG2, NPTXR, NR1D2, NUDT21, PI4K2B, PIK3C2A, PRKCD, RAD21, RALGAPA2, RBAK, SACM1L, SCN9A, SHOC2, SLC10A7, SLC16A6, SLC19A2, SOCS4, STRN, TBPL1, TMEM151B, TMEM71, TRPM7, UBE2B, WSB1, ZNF83 | ANXA11, ARF6, CALM1 (up), CLIP1, FKBP1A, G3BP2, HYOU1, MARCKS, PDCD6IP, PI4K2A, PRRC2C, SYNC, TMEM165, YWHAB, YWHAZ |
| miR-20b | 0.441 (up) | 0.100 | BCL6B, EREG, FBXO31, FIBIN, GUCY1A3, HSPA8, INO80, MAP3K9, MAST3, MCF2L, PANX2, PEX5L, PLA2G6, RAB5B, SERTAD2, SMOC2, SPG20, TMBIM6, TNFRSF21, TNS1, TPRG1L, WEE1, ZC3H7B | ACTR1A, AP2B1, ARHGAP1, FAM129A, HOOK3, KPNA2, MARS, MCM3, PTBP1, SYNCRIP, TRIM3 |
| miR-23a | 0.499 (up) | 0.058 | BTAF1, EGLN2, GABRB3, GABRB3, MAP3K9, MBTD1, PRKCSH, PTAR1, RAB35, RBPMS2, SIX4, TCF20, TNFAIP3 | CUL3, DDAH1, EPN1, GNPDA1, LAMP1, MRC2, NEDD4, PICALM, PIGS, PXDN, SET, TMED5, TXNRD1 |
| miR-494 | −0.564 (down) | 0.029 | APC, ARHGEF12, ATP7A, ATRX, C11ORF61, C20ORF103, C5ORF24, CNTN3, ENPP1, FAM169A, GK3P, GLIS3, GPATCH8, GRIK2, INHBB, KDM5C, KIAA0776, KIAA1549, KIAA2022, LANCL2, LOC344593, LRP1B, MBNL3, NANOS1, PNOC, PSD3, PTPRE, RAB40B, RTF1, SCN2B, SLC26A3, SLC38A2, SSX2IP, TAC1, TACC2, TCF20, TRAF3, TRPS1, ZBTB39, ZBTB43 | SEPT9, DPYSL3, FAM120A, H3F3A, MAP4, MTDH, PIP4K2B, PITPNB, PTPN11, PURB, SYNCRIP, THRAP3 |
| miR-29c | 0.488 (up) | 0.065 | ARF5, COL6A3, CSPG4, DDX3X (down), HNRNPF, ITGB1, LOX, PRKRA, PRRC2C, PTX3, SYNCRIP ARF6, PRPF19 | |
| miR-28-3p | 0.454 (up) | 0.089 | ARF6, PRPF19 | |
| miR-409-3p | −0.461 (down) | 0.083 | BUB3, CALM1 (up), CDV3, COL5A2, EWSR1, HNRNPK, LARP1, MYLK, SH3BGRL3, SLC2A12, TMED7, UBE2N, YWHAE | |
| miR-409-5p | −0.522 (down) | 0.046 | DLST, FAM129A |