Table 4. Proteins with unique amino acids in the bowhead whale compared to 67 vertebrates.
AA changes correspond to residue locations in the translated human RefSeq mRNA entry (typically the longest RefSeq entry of each gene). Genes shown in bold were checked by BLAST analysis of raw sequence data. Some of the genes in this table, especially those not shown in bold, may be false-positives.
| Gene name | Symbol (human) | RefSeq ID | AA change(s) |
|---|---|---|---|
| actin-binding Rho activating protein | ABRA | NM_139166 | HKR283P |
| adaptor-related protein complex 3, beta 1 subunit | AP3B1 | NM_003664 | R1086Q |
| annexin A7 | ANXA7 | NM_001156 | Y410C |
| arachidonate 5-lipoxygenase | ALOX5 | NM_000698 | D204N |
| calcium homeostasis modulator 2 | CALHM2 | NM_015916 | F172C |
| calsyntenin 2 | CLSTN2 | NM_022131 | Q362H |
| cell division cycle associated 7 | CDCA7 | NM_145810 | ED257K |
| c-fos induced growth factor (vascular endothelial growth factor D) | FIGF | NM_004469 | STQ174R |
| ClpB caseinolytic peptidase B homolog (E. coli) | CLPB | NM_001258392 | HR226W |
| complement component 5 | C5 | NM_001735 | I760K |
| cytidine and dCMP deaminase domain containing 1 | CDADC1 | NM_030911 | YQ367C |
| derlin 1 | DERL1 | NM_024295 | R197G |
| enhancer of polycomb homolog 1 (Drosophila) | EPC1 | NM_001272004 | G562R |
| erythrocyte membrane protein band 4.1-like 1 | EPB41L1 | NM_001258329 | K478M |
| fucose-1-phosphate guanylyltransferase | FPGT | NM_003838 | HK339E |
| gem (nuclear organelle) associated protein 4 | GEMIN4 | NM_015721 | KR721T |
| gigaxonin | GAN | NM_022041 | E74V |
| glutamate receptor, ionotropic, kainate 2 | GRIK2 | NM_175768 | Y571C, Q621R |
| glutamate receptor, metabotropic 1 | GRM1 | NM_001278066 | E559D |
| heat shock protein 90kDa alpha (cytosolic), class B member 1 | HSP90AB1 | NM_001271971 | H121T |
| homeodomain interacting protein kinase 1 | HIPK1 | NM_181358 | SP465C |
| homeodomain interacting protein kinase 3 | HIPK3 | NM_005734 | Q698H |
| ligase III, DNA, ATP-dependent | LIG3 | NM_013975 | D255N |
| mitogen-activated protein kinase kinase kinase 7 | MAP3K7 | NM_145331 | V424D |
| MMS19 nucleotide excision repair homolog (S. cerevisiae) | MMS19 | NM_022362 | SLT202C |
| Nance-Horan syndrome (congenital cataracts and dental anomalies) | NHS | NM_001291868 | R388Q |
| NEDD4 binding protein 3 | N4BP3 | NM_015111 | Q384H |
| neuronal pentraxin II | NPTX2 | NM_002523 | Q375H |
| NOP2 nucleolar protein | NOP2 | NM_001258310 | YF516C |
| NRDE-2, necessary for RNA interference, domain containing | NRDE2 | NM_017970 | H592Q |
| nuclear receptor coactivator 2 | NCOA2 | NM_006540 | F441C |
| nuclear receptor coactivator 7 | NCOA7 | NM_181782 | SAT160D |
| nucleolar protein 6 (RNA-associated) | NOL6 | NM_022917 | R582L |
| oncoprotein induced transcript 3 | OIT3 | NM_152635 | P353R |
| oxidative stress induced growth inhibitor family member 2 | OSGIN2 | NM_004337 | ED194K |
| PALM2-AKAP2 readthrough | PALM2-AKAP2 | NM_147150 | ED488G |
| patched 1 | PTCH1 | NM_000264 | S1185C |
| phosphodiesterase 4D interacting protein | PDE4DIP | NM_001002811 | SGNTP264R |
| polymerase (DNA-directed), delta interacting protein 3 | POLDIP3 | NM_032311 | Q198R |
| potassium voltage-gated channel, Shal-related subfamily, member 2 | KCND2 | NM_012281 | L457R |
| protein kinase, cAMP-dependent, regulatory, type I, alpha | PRKAR1A | NM_212472 | N26D |
| protocadherin alpha subfamily C, 2 | PCDHAC2 | NM_018899 | K884Q |
| serpin peptidase inhibitor, clade C (antithrombin), member 1 | SERPINC1 | NM_000488 | E359D |
| striatin, calmodulin binding protein | STRN | NM_003162 | ED279V |
| transmembrane protein 214 | TMEM214 | NM_017727 | R251Q |
| transmembrane protein 25 | TMEM25 | NM_032780 | G162D |
| tripartite motif containing 29 | TRIM29 | NM_012101 | Q250H |
| tyrosine aminotransferase | TAT | NM_000353 | Y442H |
| vacuolar protein sorting 13 homolog B (yeast) | VPS13B | NM_015243 | G567R |