. 2014 Nov 5;88(12):2135–2190. doi: 10.1007/s00204-014-1382-8

Table 1.

Representative cytochrome P450 (CYP) basal activities in skin microsomes of various mammalian species

Activity (preferential for)	Human	Rat	Mouse	Guinea pig	Pig
AHH (CYP1 family)	0.24–1.35^a	1.25 ± 0.11^a	m^b: 3.3–8^a; f^b: 17–21^a	2.51 ± 0.35^a
EROD (CYP1 family)	bd–35^a	m: 3.6 ± 0.3; f: 1.5 ± 0.2^a	m: bd; f: 3–19^a		4.62 ± 0.54^b
ECOD (CYP1A, 2B)	bd–12^a	0.36–2.15^a	10.4–80^a	3.8 ± 2.7^a	(13.2 ± 2.5^b)
MROD (CYP1A2)	bd to +
PROD (CYP2B)	bd to bq	m: 3.7 ± 1.3; f: 1.8 ± 0.1^a	m: bq; f: 0.1–1.7^a	bq	bd
BROD (CYP3A, 2B)		m: 4.4 ± 0.9; f: 2.1 ± 0.2^a
Aminopyrine-N-demethylase (CYP2B, 3A)		1,000–4200^a	+
Tolbutamide 4-hydroxylation (CYP2C9)	0.46 ± 0.05^b	0.47 ± 0.04^b	bd		1.66 ± 0.49^b
Bufuralol 1-hydroxylation (CYP2D6)	bd	1.33 ± 0.17^b	9.23 ± 0.67^b		0.26 ± 0.03^b
Chlorzoxazone 6-hydroxylation (CYP2E1)	2.83 ± 0.34^b	bd	20.8 ± 0.5^b		bd
Para-nitrophenol hydroxylation (CYP2E1)	bd/+	bd^c	f: 40 ± 10^a
Midazolam 1-hydroxylation (CYP3A)	2.35 ± 0.23^b	0.58 ± 0.09^b	8.70 ± 0.28^b		2.32 ± 0.21^b
Benzoquinoline O-dealkylation (CYP3A)	bd–76 ± 41^a
Erythromycin N-demethylation (CYP3A)	+	bd–270^a	f: 540–1100^a

More examples and references in the text

AHH aryl hydrocarbon hydroxylase, phenolic benzo[a]pyrene metabolites determined with 3-hydroxy-benzo[a]pyrene as standard, bd below detection, BROD 7-benzyloxyresorufin O-debenzylase, bq below quantification, ECOD 7-ethoxycoumarin O-deethylase, EROD 7-ethoxyresorufin O-deethylase, f female, m male, MROD 7-methoxyresorufin O-demethylase, PROD pentoxyresorufin O-depentylase

^apmol/mg protein/min

^bpmol/mg protein/h, numbers in brackets: in medium of short-term culture

^cIn epidermal microsomes