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Important research gaps in human modelsa
| CYPb 1A2 (almost no data) |
|---|
| CYP2Cs (very few data) |
| CYP2D6 (almost no data) |
| CYP2E1 (almost no data) |
| FMO (very few data) |
| COX (very few data) |
| ADH and ALDH (very few data) |
| EH (almost no data) |
COX cyclooxygenase, CYP cytochrome P450, ADH alcohol dehydrogenase, ALDH aldehyde dehydrogenase, EH epoxide hydrolase, FMO flavin-dependent monooxygenase
aPrimary cells, cell lines, reconstructed skin models compared with human skin
