Table 5.
Representative UDP-glucuronosyl (UGT) and sulfotransferase (SULT) activities in skin of various mammalian species
| Substrate (for) | Human | Rat | Mouse | Pig |
|---|---|---|---|---|
| 4-Methylumbelliferone (UGT) | 1.3 ± 0.2a | 11.1 ± 9.65b | ||
| Bilirubin (UGT) | + | 15–23a | ||
| 4-Hydroxybiphenyl (UGT) | <0.08a | |||
| 7-Hydroxycoumarin (UGT) | <0.333 ± 0.032c | |||
| 1-Naphthol (UGT) | 2.5–13a | |||
| 3-Hydroxybenzo[a]pyrene (UGT) | 0.08 ± 0.01a | |||
| Testosterone (UGT) | <0.09a | |||
| Salicylic acid (UGT) | 0.0062–0.016a | |||
| Acetaminophen (UGT) | + (Tentative) | + (Tentative) | ||
| Acetaminophen (SULT) | + (Tentative) | + (Tentative) | ||
| 7-Hydroxycoumarin (SULT) | <0.183 ± 0.029c | |||
| 4-Nitrophenol (SULT) | Traces—0.18 ± 0.02d,e | |||
| Minoxidil (SULT1A1) | 0.21 ± 0.02d | 0.006f | ||
| Dopamine (SULT) | 0.60 ± 0.05d |
More examples and references in the text; only constitutive activities
UGT UDP-glucuronosyltransferase, SULT sulfotransferase
anmol product/min/mg microsomal protein
b nmol/min/g of skin
c nmol/h/g of skin analyzed in the culture medium
d nmol/h/mg “high-speed supernatant” protein
e pmol/min/mg protein (sum of 7,500g supernatant + medium)
f nmol product/min/mg cytosolic protein