Table 7.

Overview of frequently used cell lines for studies on cutaneous xenobiotic-metabolizing enzymes

Cell line	Type	Reference and/or origin
HaCaT	Spontaneously immortalized aneuploid immortal, but non-tumorigenic human keratinocytic cell line	Boukamp et al. (1988)
NCTC 2544	Human breast skin keratinocyte-derived cell line	Bakken et al. (1961)
KeratinoSens®	Possess a luciferase gene under control of the human aldo keto reductase AKR1 C2 antioxidant response element (ARE)	Givaudan
LuSens	Derived from human keratinocytes; possess a luciferase gene under control of the rat NADH/NADPH quinone reductase NQO1 antioxidant response element (ARE)	Bauch et al. 2011; Ramirez et al. 2014/BASF SE
U937	Established from a diffuse histiocytic lymphoma displaying many monocytic characteristics	Galvão dos Santos et al. 2009/DSMZ, Braunschweig
THP-1	Derived from the blood of a patient with acute monocytic leukemia	Qin 2012/DSMZ, Braunschweig

DSMZ Deutsche Sammlung von Mikroorganis-men und Zellkulturen GmbH (German Collection of Microorganisms and CellCultures)