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. 2014 Nov 5;88(12):2135–2190. doi: 10.1007/s00204-014-1382-8

Table 8.

Overview of commercially available reconstructed human skin modelsa

Skin model Type Company Cell origin Reference
EpiDerm™ (EPI-200) Epidermal MatTek, MA, USA Male foreskin Hayden et al. (2006)
EpiDermFT™ (EFT) Full thickness (collagen matrix) MatTek, MA, USA Male foreskin Hayden et al. (2003)
EST-1000 (EST) Epidermal Cell Systems, Troisdorf, Germany Male foreskin Hoffmann et al. (2005)
AST-2000 (AST) Full thickness (collagen matrix) Cell Systems, Troisdorf, Germany Male foreskin Hoffmann et al. (2003)
Episkin™ Epidermal SkinEthic™ laboratories, Nice, France Adult breast skin

Tinois et al. (1991)

Netzlaff et al. (2005)

Episkin™ FTM Full thickness (polycarbonate and collagen matrix) SkinEthic™ laboratories, Adult breast skin Eilstein et al. (2010)
SkinEthik™ RHE Epidermal SkinEthic™ laboratories, Nice, France

Adult abdomen

Male foreskin

Netzlaff et al. (2005)

Eilstein et al. (2014)

Phenion® FT (PFT) Full thickness (collagen matrix) Henkel, Düsseldorf, Germany Male foreskin Mewes et al. (2007)
StrataTest® Epidermal StrataTech, MA, USA NIKS® human keratinocyte cell line Slavik et al. (2007)
EuroSkin® Epidermal EuroDerm, Leipzig, Germany Hair follicles http://www.eurodermbiotech.de (2011)
EPI-MODEL Epidermal LabCyte, Aichi, Japan ? Katoh et al. (2009)

NIKS®, spontaneously immortalized near-diploid human keratinocyte cell line

aAdapted from: Jäckh et al. (2012)