Table II.

Association of selected SNPs on 5p15, 15q25 and 6p21 loci with lung cancer risk by cancer type

Marker (minor allele)	Type	MAF case/controla	P value	OR (95% CI)b	P het
Chromosome 15q25
rs16969968 (A)	All cancers	0.43/0.36	0.00001	1.38 (1.19, 1.60)
	Adenocarcinoma	0.44/0.36	0.0001	1.45 (1.20, 1.74)	0.99
	Squamous cell carcinoma	0.44/0.36	0.007	1.45 (1.10, 1.91)
rs8042374 (G)	All cancers	0.19/0.24	0.006	0.78 (0.65, 0.93)
	Adenocarcinoma	0.19/0.24	0.032	0.77 (0.61, 0.98)	0.26
	Squamous cell carcinoma	0.16/0.24	0.007	0.60 (0.42, 0.87)
rs8034191c (C)	All cancers	0.43/0.35	0.000003	1.42 (1.22, 1.64)
	Adenocarcinoma	0.44/0.35	0.00006	1.46 (1.21, 1.77)	0.96
	Squamous cell carcinoma	0.44/0.35	0.007	1.45 (1.11, 1.91)
Chromosome 5p15
rs2736100 (T)	All cancers	0.46/0.50	0.056	0.87 (0.75, 1.00)
	Adenocarcinoma	0.43/0.50	0.004	0.76 (0.63, 0.92)	0.03
	Squamous cell carcinoma	0.52/0.50	0.492	0.91 (0.69, 1.19)
rs4635969 (T)	All cancers	0.19/0.19	0.708	0.97 (0.80, 1.16)
	Adenocarcinoma	0.19/0.19	0.796	0.97 (0.76, 1.23)	0.72
	Squamous cell carcinoma	0.18/0.19	0.547	0.90 (0.63, 1.28)
rs402710 (T)	All cancers	0.31/0.33	0.339	0.93 (0.79, 1.08)
	Adenocarcinoma	0.30/0.33	0.129	0.85 (0.70, 1.05)	0.99
	Squamous cell carcinoma	0.31/0.33	0.306	0.86 (0.64, 1.15)
rs401681 (T)	All cancers	0.42/0.44	0.370	0.94 (0.81, 1.08)
	Adenocarcinoma	0.41/0.44	0.282	0.91 (0.75, 1.09)	0.73
	Squamous cell carcinoma	0.40/0.44	0.248	0.87 (0.64, 1.12)
Chromosome 6p21
rs3131379 (T)	All cancers	0.07/0.10	0.032	0.74 (0.57, 0.98)
	Adenocarcinoma	0.08/0.10	0.336	0.85 (0.61, 1.19)	0.68
	Squamous cell carcinoma	0.07/0.10	0.266	0.75 (0.45, 1.25)

P _het, P value for heterogeneity by histology derived from the Cochran Q test. P values <0.05 are shown in bold. ^aMinor allele frequency.

^bEstimated ORs are for the minor alleles.

^cIn LD with rs16969968 (r ² = 0.9), but directly assayed (not imputed) in cases and controls.