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. 2014 Oct 3;35(12):2731–2739. doi: 10.1093/carcin/bgu200

Fig. 2.

Fig. 2.

Expression status of HOTAIR in GC cell lines and functional analysis using siRNA transfection. (a) HOTAIR expression status in gastric cancer cell lines. (b) Knockdown of HOTAIR expression 48h after transfection in MKN45 and KATOIII GC cell lines. HOTAIR gene expression was downregulated dramatically after HOTAIR knockdown. (c) Effect of HOTAIR suppression on MKN45 and KATOIII cell proliferation as assessed by the MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) assay. (d) Cell cycle analysis demonstrated that the G0/G1 fraction increased after HOTAIR knockdown. Each value represents the mean ± SE. *P < 0.05.