Table II.
SNPs in the 9p21 region significantly associated with individual cancers after Bonferroni correctiona
| Gene | SNP (major, minor allele) | Location | MAF: cases, controls | OR (95% CI) | P |
|---|---|---|---|---|---|
| BC | |||||
| 3′ of TUSC1 | rs2764736 (T, C) | 25057731 | 0.015, 0.027 | 0.36 (0.26–0.49) | 5.29×10−11 |
| ESCC | |||||
| 3′ UTR of CDKN2B | rs1063192 (T, C) | 21993367 | 0.235, 0.194 | 1.29 (1.16–1.44) | 2.45×10−6 |
| CDKN2B-AS1 intronic | rs2157719 (A, G) | 22023366 | 0.141, 0.108 | 1.38 (1.21–1.58) | 2.59×10−6 |
MAF, minor allele frequency.
aSNPs significant after Bonferroni correction for multiple comparisons (P < 3.65×10−6), ranked by P values. The P values and odds ratios (ORs) (per one minor allele) were calculated from random-effect meta-analysis (LC) or logistic regression models (other cancers), adjusting for cancer-specific covariates.