Table IV.
Gene-level P values with number of SNPs for 9p21 genes in eight cancersa
| Gene | Starting | Ending | ESCC | GC | PanC | RCC | LC | BrC | BC | PrC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | P | No. | P | No. | P | No. | P | No. | P | No. | P | No. | P | No. | P | |||
| IFNB1 | 21067104 | 21087943 | 4 | 0.66 | 4 | 0.80 | 4 | 0.79 | 4 | 0.02 | 4 | 0.30 | 5 | 0.14 | 7 | 0.12 | 5 | 0.63 |
| IFNW1 | 21120631 | 21152144 | 7 | 0.15 | 7 | 0.28 | 8 | 0.72 | 8 | 0.36 | 8 | 0.68 | 8 | 0.23 | 10 | 0.14 | 8 | 0.54 |
| IFNA21 | 21145636 | 21176659 | 3 | 0.95 | 3 | 0.81 | 3 | 0.31 | 4 | 0.98 | 3 | 0.23 | 3 | 0.55 | 8 | 0.82 | 3 | 0.24 |
| IFNA4 | 21166693 | 21197670 | 5 | 0.95 | 5 | 0.52 | 5 | 0.09 | 7 | 0.92 | 4 | 0.48 | 5 | 0.90 | 8 | 0.50 | 5 | 0.36 |
| IFNA7 | 21181468 | 21212204 | 4 | 0.94 | 4 | 0.50 | 4 | 0.09 | 5 | 0.91 | 3 | 0.47 | 4 | 0.90 | 7 | 0.57 | 4 | 0.36 |
| IFNA10 | 21186180 | 21217142 | 3 | 0.93 | 3 | 0.49 | 3 | 0.08 | 4 | 0.90 | 3 | 0.47 | 4 | 0.90 | 7 | 0.57 | 4 | 0.36 |
| IFNA16 | 21196372 | 21227310 | — | — | — | — | — | — | — | — | — | — | 1 | 0.74 | 4 | 0.84 | 1 | 0.75 |
| IFNA17 | 21207242 | 21238221 | 1 | 0.44 | 1 | 0.85 | 1 | 0.14 | 2 | 0.69 | 1 | 0.44 | 1 | 0.97 | 4 | 0.41 | 1 | 0.74 |
| IFNA14 | 21219201 | 21249978 | 3 | 0.64 | 2 | 0.82 | 3 | 0.26 | 4 | 0.86 | 3 | 0.58 | 3 | 0.24 | 5 | 0.45 | 3 | 0.27 |
| IFNA5 | 21284686 | 21315255 | 7 | 0.91 | 7 | 0.56 | 7 | 0.04 | 9 | 0.95 | 6 | 0.89 | 6 | 0.98 | 10 | 0.97 | 7 | 0.75 |
| KLHL9 | 21311018 | 21345429 | 6 | 0.83 | 6 | 0.24 | 6 | 0.02 | 6 | 0.21 | 6 | 0.27 | 6 | 0.52 | 10 | 0.62 | 6 | 0.82 |
| IFNA6 | 21330317 | 21360886 | 3 | 0.54 | 3 | 0.22 | 3 | 0.01 | 4 | 0.14 | 3 | 0.15 | 3 | 0.31 | 11 | 0.89 | 3 | 0.58 |
| IFNA13 | 21347423 | 21378075 | 3 | 0.08 | 3 | 0.05 | 3 | 0.03 | 4 | 0.78 | 3 | 0.79 | 3 | 0.42 | 12 | 0.92 | 3 | 0.80 |
| IFNA2 | 21364254 | 21395396 | 6 | 0.13 | 6 | 0.09 | 6 | 0.04 | 6 | 0.86 | 6 | 0.89 | 6 | 0.57 | 12 | 0.80 | 6 | 0.93 |
| IFNA8 | 21379146 | 21410184 | 6 | 0.54 | 6 | 0.23 | 9 | 0.24 | 9 | 0.27 | 9 | 0.88 | 8 | 0.56 | 14 | 0.89 | 9 | 0.60 |
| IFNA1 | 21410440 | 21441315 | 4 | 0.56 | 4 | 0.21 | 5 | 0.71 | 5 | 0.10 | 4 | 0.53 | 5 | 0.82 | 6 | 0.29 | 5 | 0.51 |
| IFNE1 | 21460839 | 21492312 | 7 | 0.75 | 7 | 0.008 | 7 | 0.24 | 6 | 0.006 | 4 | 0.18 | 5 | 0.33 | 10 | 0.96 | 6 | 0.45 |
| MTAP | 21772635 | 21865969 | 16 | 0.04 | 16 | 0.81 | 20 | 0.62 | 19 | 0.17 | 19 | 0.08 | 21 | 0.22 | 42 | 0.02 | 20 | 0.94 |
| CDKN2A | 21947751 | 22004490 | 15 | 2.70×10 −5b | 15 | 0.06 | 16 | 0.56 | 15 | 0.88 | 15 | 0.09 | 15 | 0.52 | 23 | 0.11 | 15 | 0.52 |
| CDKN2B-AS1 | 21964790 | 22121093 | 31 | 4.70×10 −5b | 31 | 0.22 | 32 | 0.43 | 31 | 0.70 | 30 | 0.13 | 30 | 0.92 | 46 | 0.16 | 31 | 0.35 |
| CDKN2B | 21982902 | 22019312 | 10 | 1.80×10 −5b | 10 | 0.36 | 11 | 0.40 | 10 | 0.88 | 10 | 0.05 | 10 | 0.91 | 15 | 0.07 | 10 | 0.36 |
| DMRTA1 | 22416840 | 22452472 | 10 | 0.47 | 10 | 0.28 | 10 | 0.32 | 10 | 0.70 | 10 | 0.19 | 10 | 0.24 | 15 | 0.42 | 10 | 1.00 |
| ELAVL2 | 23670103 | 23836063 | 51 | 0.07 | 51 | 0.39 | 53 | 0.03 | 52 | 0.94 | 51 | 0.84 | 49 | 0.92 | 67 | 0.99 | 50 | 0.94 |
| TUSC1 | 25656387 | 25688856 | 5 | 0.77 | 5 | 0.13 | 6 | 0.85 | 6 | 0.98 | 6 | 0.64 | 6 | 0.80 | 8 | 0.14 | 6 | 0.40 |
| C9orf82 | 26820683 | 26902725 | 8 | 0.64 | 8 | 0.52 | 6 | 0.88 | 9 | 0.86 | 9 | 0.73 | 9 | 0.39 | 20 | 0.34 | 9 | 0.32 |
| PLAA | 26884518 | 26957139 | 6 | 0.77 | 6 | 0.17 | 10 | 0.50 | 10 | 0.74 | 9 | 0.99 | 10 | 0.79 | 23 | 0.37 | 10 | 0.17 |
| IFT74 | 26926371 | 27062931 | 10 | 0.41 | 10 | 0.41 | 14 | 0.54 | 17 | 0.83 | 17 | 0.71 | 17 | 0.81 | 32 | 0.57 | 19 | 0.31 |
| LRRC19 | 26973586 | 27015670 | 1 | 0.39 | 1 | 0.16 | 2 | 0.39 | 2 | 0.31 | 2 | 0.42 | 2 | 0.38 | 7 | 0.43 | 3 | 0.11 |
| TEK | 27079147 | 27230172 | 72 | 0.51 | 72 | 0.28 | 84 | 0.26 | 86 | 0.76 | 84 | 0.48 | 83 | 0.17 | 110 | 0.69 | 84 | 0.46 |
| C9orf11 | 27264667 | 27307137 | 19 | 0.79 | 19 | 0.96 | 22 | 0.46 | 21 | 0.54 | 20 | 0.15 | 21 | 0.24 | 31 | 0.77 | 21 | 0.45 |
| MOB3B | 27305207 | 27539850 | 63 | 0.87 | 63 | 0.36 | 73 | 0.01 | 73 | 0.10 | 69 | 0.18 | 69 | 0.41 | 105 | 0.26 | 69 | 0.60 |
| IFNK | 27494312 | 27526496 | 8 | 0.97 | 8 | 0.90 | 8 | 0.75 | 8 | 0.55 | 8 | 0.40 | 8 | 0.66 | 14 | 0.97 | 8 | 0.16 |
| C9orf72 | 27526544 | 27583476 | 20 | 0.60 | 20 | 0.52 | 19 | 0.81 | 19 | 0.71 | 18 | 0.41 | 17 | 0.89 | 28 | 0.98 | 18 | 0.10 |
| LINGO2 | 27928528 | 28729303 | 239 | 0.74 | 240 | 0.19 | 269 | 0.05 | 274 | 0.31 | 258 | 0.87 | 261 | 0.10 | 344 | 0.49 | 263 | 0.29 |
| ACO1 | 32354601 | 32440834 | 19 | 0.02 | 19 | 0.05 | 24 | 0.68 | 24 | 0.46 | 23 | 0.50 | 24 | 0.88 | 35 | 0.21 | 25 | 0.03 |
aGenes were ordered by the chromosome location and those with P < 0.01 were marked in bold.
bSignificant after multiple comparison adjustment [P < 0.05/(35 genes × 8 studies)] = 1.79×10−4.