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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Cancer Res. 2014 Jan 21;74(5):1329–1337. doi: 10.1158/0008-5472.CAN-13-3014

Figure 2. SF induces increased tumor invasiveness.

Figure 2

A) Representative H&E sections of the TC1 tumors and the adjacent muscular tissue (cells were injected s.c. in the thigh area), increased invasiveness was apparent in SF-C57/B6 tumors compared to SC-C57/B6 conditions, with obvious penetration of surrounding tumor capsule and extension/infiltration into adjacent muscle. B) (i). Representative live MMP imaging (n=6/group) showing statistically significant increases in MMP activity in SF-C57/B6 tumors vs. CS-C57/B6. (ii). Significant differences in MMP activity continued to be apparent after 12 and 24h, with higher activity in SF vs. SC tumors. *p< 0.05