Table 2.
NMA Fixed effects results, SMDs converted to log odds ratios for slowing the decline in FVC
Log odds ratios | Odds ratios | |||||||
---|---|---|---|---|---|---|---|---|
Comparator (vs. placebo) | N studies | Total N participants | Mean | 95% CrI | Mean | 95% CrI | ||
Azathioprine | 1 | 19 | 0.44 | -0.30 | 1.19 | 1.56 | 0.74 | 3.29 |
Nintedanib | 1 | 170 | -0.97 | -1.52 | -0.41 | 0.38 | 0.22 | 0.66 |
NAC triple therapy | 2 | 294 | -0.06 | -0.60 | 0.48 | 0.94 | 0.55 | 1.62 |
Inhaled NAC | 1 | 76 | -0.42 | -1.24 | 0.40 | 0.66 | 0.29 | 1.49 |
Pirfenidone | 4 | 1006 | -0.39 | -0.62 | -0.16 | 0.68 | 0.54 | 0.85 |
Sildenafil | 1 | 180 | -0.12 | -0.65 | 0.41 | 0.89 | 0.52 | 1.51 |
Head-to-head comparison | ||||||||
Nintedanib vs. Pirfenidone | -0.58 | -1.18 | 0.03 | 0.56 | 0.31 | 1.03 |