Table 6.

Number of events, stratified by (log)SFRP4 tertiles

	HR	95%-CI	p-Value
All primary endpoints	1.05	0.76 - 1.45	0.77
Acute coronary syndrome	1.65	0.89 – 3.08	0.12
MACE*	0.91	0.60 – 1.38	0.64
Stroke/TIA	2.45	1.07 – 5.59	0.034
Cardiovascular death + non-fatal MI	0.99	0.50 – 1.99	0.99
All-cause death	2.02	0.91 – 4.50	0.084

Univariate cox proportional hazards regression analyses were used to compare time to events between (log)SFRP4 tertiles. Hazard ratios (HR) and 95% confidence intervals (95%-CI) are provided for the comparison of the third tertile vs. the first tertile (reference category, HR =1.0).

*MACE = Major adverse cardiovascular events (Combination of myocardial infarction, unplanned revascularization and cardiovascular death).