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. 2014 Sep 4;10:56. doi: 10.1186/1744-8069-10-56

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© Guindon et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Kidney functions assessment in saline or cisplatin-treated groups receiving different pretreatments (saline, NaHCO _3, vitamin C, or resveratrol). (A) Creatinine levels were increased in saline/cisplatin and resveratrol/cisplatin groups relative to control/saline treatment. Both vitamin C and NaHCO₃ pretreatments blocked cisplatin-induced increases in creatinine levels. (B) Ketone levels are increased in saline/cisplatin group but not in control/saline, vitamin C, NaHCO₃ or resveratrol/cisplatin-treated groups. (C) Glucose levels and (D) blood pH did not differ between control/saline or any cisplatin-treated group. (E) Urine pH was elevated in the NaHCO₃/cisplatin group in comparison to control/saline, saline/cisplatin or vitamin C/cisplatin groups. (F) Kidney weight ratios are increased in saline/cisplatin and resveratrol/cisplatin groups relative to control/saline, vitamin C or NaHCO₃ treated groups. Data are expressed as mean ± s.e.m. (n = 8 per group). *P < 0.001 vs. control/saline, vitamin C or NaHCO3/cisplatin groups (ANOVA, Bonferroni post hoc); + P < 0.0001 vs. control/saline, vitamin C, NaHCO₃ or resveratrol/cisplatin-treated groups (ANOVA, Bonferroni post hoc); # P < 0.0001 vs. control saline, saline/cisplatin or vitamin C/cisplatin groups (ANOVA, Bonferroni post hoc).