Table 4.
Activity of replicate plant extracts listed by plant part and collection site
| Genus and Species | Voucher Number | Plant Part | PNG Province | CYP1A2 Induction (- fold) |
CYP3A4 Induction (- fold) |
CYP1A2 % Inhibition |
CYP3A4 % Inhibition |
CYP2D6 % Inhibition |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MR (2.0 μM) | MR (0.4 μM) | 7-BQ (500 μM) | 7-BQ (100 μM) | MAMC (100 μM) | MAMC (40 μM) | ||||||
| A. conyzoides | sk013 | leaves & flowers | Eastern Highlands | -- | -- | -- | -- | -- | -- | -- | -- |
| A. conyzoides | em021 | leaves | Southern Highlands | -- | -- | -- | -- | -- | -- | -- | -- |
| A. evecta | em046 | vines | Southern Highlands | -- | -- | -- | -- | -- | -- | -- | -- |
| A. evecta | cw055 | leaves | Western Highlands | -- | -- | -- | -- | -- | 50 | -- | -- |
| B. pilosa | em028 | leaves | Southern Highlands | -- | 5.7 | -- | -- | -- | -- | -- | -- |
| B. pilosa | cw004 | leaves | Western Highlands | -- | 5.5 | -- | -- | -- | -- | -- | 51 |
| C. papaya | in032 | whole plant | North Bouganville | -- | -- | -- | -- | -- | -- | -- | -- |
| C. papaya | em016 | leaves | Southern Highlands | -- | -- | -- | -- | 54 | 78 | -- | -- |
| C. papaya | cw026 | flowers, leaves & white sap | Western Highlands | -- | -- | -- | -- | -- | -- | -- | -- |
| C. alata | nn050 | leaves | Manus | -- | -- | -- | 54 | -- | -- | 56 | 61 |
| C. alata | in014 | leaves | North Bouganville | -- | -- | 58 | 75 | -- | 57 | 54 | -- |
| C. asiatica | jp1165 | whole plant | Enga | -- | -- | -- | -- | -- | 56 | -- | -- |
| C. asiatica | nn014 | leaves | Manus | -- | -- | -- | -- | -- | -- | -- | -- |
| C. asiatica | cw069 | leaves | Western Highlands | -- | -- | -- | -- | -- | -- | -- | -- |
| C. variegatum | nn016 | leaves | Manus | 5.8 | 14.2 | -- | -- | 67 | 97 | 50 | 60 |
| C. variegatum | in031 | leaves | North Bouganville | -- | -- | -- | -- | -- | -- | -- | -- |
| C. variegatum | in006 | leaves, stalk & sap | North Bouganville | -- | -- | -- | -- | -- | -- | -- | -- |
| C. terminalis | jp1144 | leaves | Enga | -- | -- | -- | -- | -- | 76 | -- | -- |
| C. terminalis | cw030 | leaves from shoots | Western Highlands | -- | 3.8 | -- | -- | -- | 88 | 50 | 61 |
| E. indica | nn012 | leaves | Manus | -- | -- | -- | -- | -- | -- | -- | -- |
| E. indica | in060 | whole plant | North Bouganville | -- | -- | -- | -- | -- | -- | -- | -- |
| F. septica | in008 | bark | Manus | -- | -- | -- | -- | -- | -- | -- | -- |
| F. septica | nn006 | leaves & shoots | North Bouganville | -- | -- | -- | -- | -- | -- | -- | -- |
| P. guajava | sk002 | leaves | Eastern Highlands | -- | 5.2 | 52 | 57 | 53 | 85 | 59 | -- |
| P. guajava | nn011 | leaves | Manus | -- | 4.6 | -- | 55 | -- | 62 | -- | -- |
| P. guajava | in045 | leaves | North Bouganville | -- | 8.7 | -- | -- | -- | 50 | 51 | 51 |
| P. guajava | em009 | leaves | Southern Highlands | -- | 5.8 | 57 | 72 | 55 | 79 | 52 | 58 |
| P. guajava | cw019 | leaves | Western Highlands | -- | 3.5 | 58 | 66 | -- | 66 | -- | -- |
| S. torvum | jp1126 | whole plant | Enga | -- | -- | -- | -- | -- | -- | -- | -- |
| S. torvum | in017 | leaves | North Bouganville | -- | -- | -- | -- | -- | -- | -- | 52 |
CYP Induction: (--) activity was < 4.0-fold (CYP1A2) & < 3.5-fold (CYP3A4); CYP Inhibition: (--) activity was < 50% inhibition; methoxyresorufin (MR), 7-benzoxyquinoloine (7-BQ), 7-methoxy-4-(aminomethyl)-coumarin (MAMC).