Ratio between total (sum of esterified and free) and free oxylipins (total:free-ratio) in plasma at baseline (t0) and after twelve weeks (t12) of treatment with LC n-3 PUFA. Ratios of hydroxy, epoxy and dihydroxy fatty acids derived from A) linoleic acid (LA C18:2 n-6), B) arachidonic acid (AA C20:4 n-6), C) alpha-linolenic acid (ALA C18:3 n-3), D) eicosapentaenoic acid (EPA C20:5 n-3) and E) docosahexaenoic acid (DHA C22:6 n-3) are shown. Significant differences were determined by dependent sample t-test. * p<0.05, ** p<0.005, *** p<0.001.