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. 2014 Nov 30;32(1):399. doi: 10.1007/s12032-014-0399-4

Table 2.

Total and stratified analyses of the DNMT3B −149C/T polymorphism on cancer risk

Variable No.a Cases/controls CC versus TT CT versus TT CC/CT versus TT CC versus CT/TT
OR (95 % CI) P b P OR (95 % CI) P b P OR (95 % CI) P b P OR (95 % CI) P b P
Total 22 5,903/8,132 0.96 [0.86, 1.09] 0.10 0.55 1.07 [0.86, 1.32] 0.00c 0.56 1.03 [0.85, 1.25] 0.00c 0.76 0.93 [0.80, 1.08] 0.01c 0.36
Ethnicities
 Occident 11 3,961/5,460 0.98 [0.87, 1.1] 0.11 0.72 1.10 [0.89, 1.37] 0.00c 0.38 1.06 [0.88, 1.28] 0.00c 0.54 0.95 [0.83, 1.09] 0.07c 0.45
 Asian 9 1,772/2,378 0.78 [0.36, 1.7] 0.15 0.53 0.87 [0.40, 1.92] 0.00c 0.74 0.91 [0.42, 1.95] 0.00c 0.81 1.60 [0.87, 2.93] 0.31 0.13
 African 1 96/222 1.16 [0.56, 2.39] NEd 0.70 1.25 [0.56, 2.39] NEd 0.54 1.21 [0.62, 2.35] NEd 0.58 0.98 [0.59, 1.63] NEd 0.94
 Mixed 1 74/72 0.44 [0.17, 1.11] NEd 0.53 1.67 [0.73, 3.80] NEd 0.22 1.04 [0.48, 2.23] NEd 0.93 0.32 [0.16, 0.67] NEd 0.02
Cancer types
 Colorectal cancer 7 2,666/4,022 1.06 [0.9, 1.25] 0.37 0.48 1.08 [0.93, 1.26] 0.67 0.32 1.07 [0.93, 1.23] 0.78 0.37 0.93 [0.74, 1.17] 0.05c 0.53
 Gastric cancer 3 623/803 NEd 1.65 [0.30, 1.42] 0.97 0.28 1.65 [0.30, 1.42] 0.97 0.28 NEd
 Head and neck cancer 2 1,069/1,331 0.80 [0.63, 1.01] 0.33 0.06 0.73 [0.59, 0.90] 0.34 0.003 1.75 [0.62, 0.92] 0.31 0.005 1.00 [0.84, 1.20] 0.67 0.98
 Hepatocellular cancer 3 304/578 1.16 [0.56, 2.39] NEd 0.70 1.18 [0.65, 2.14] 0.21 0.59 0.16 [0.65, 2.05] 0.21 0.62 0.98 [0.59, 1.63] NEd 0.94
 Breast cancer 2 452/396 0.80 [0.63, 1.01] 0.33 0.06 0.75 [0.18, 3.15] 0.00c 0.69 0.83 [0.24, 2.83] 0.00c 0.76 1.20 [0.89, 1.61] 0.37 0.24
 Other cancers 5 789/1,002 1.23 [0.83, 1.83] 0.10 0.3 1.65 [0.92, 2.93] 0.04c 0.09 1.48 [0.82, 2.68] 0.00c 0.19 0.69 [0.42, 1.13] 0.09c 0.14
Sources of controls
 Hospital based 11 2,929/3,139 0.81 [0.53, 1.22] 0.03c 0.31 0.89 [0.63, 1.26] 0.03c 0.52 0.85 [0.63, 1.17] 0.06c 0.32 0.85 [0.62, 1.15] 0.05c 0.29
 Population based 11 2,974/4,993 1.03 [0.89, 1.19] 0.51 0.68 1.19 [0.91, 1.56] 0.00c 0.21 0.15 [0.91, 1.45] 0.00c 0.24 0.96 [0.80, 1.16] 0.02c 0.69

0.00 means value <0.01

aNumber of studies

b P value of Q test for heterogeneity test

cRandom effects model was used when P value for heterogeneity test <0.10; otherwise, fixed effects model was used

dNot estimable