Table 2.
The linear regression mode for evaluating the relationship between independent variables and lipid profile in HD patients.
| Variables | Triglyceride | Total cholesterol | ||||||
|---|---|---|---|---|---|---|---|---|
| Crude |
Multivariable Forward stepwise regression |
Crude |
Multivariable Forward stepwise repression |
|||||
| β (CI 95%)1 | P value | β (CI 95%) | P value | β (CI 95%) | P value | β (CI 95%) | P value | |
| Tinzaparin use | −39.9 (−76.7, −3.0) | 0.034 | −40.8 (−75.1, −6.5) | 0.020 | −9.3 (−21.6, 3.0) | 0.138 | −13.0 (−24.5, −1.56) | 0.026 |
| Sex (male) | −13.1 (−36.3, 10.0) | 0.265 | −26.8 (−48.1, −5.4) | 0.014 | −12.8 (−20.4, −5.1) | 0.001 | −19.1 (−26.5, −11.8) | <0.001 |
| Age (per year) | −0.52 (−1.40, 0.35) | 0.240 | −0.32 (−0.61, −0.02) | 0.032 | ||||
| Diabetes | 35.1 (11.7, 58.5) | 0.003 | −11.6 (−19.4, −3.8) | 0.004 | −12.0 (−20.0, −4.0) | 0.003 | ||
| BMI (per kg/m2) | 8.51 (5.51, 11.5) | <0.001 | 6.33 (3.36, 9.31) | <0.001 | −0.12 (−1.16, 0.91) | 0.819 | ||
| SBP (per mmHg) | 0.47 (0.02, 0.91) | 0.039 | 0.54 (0.12, 0.96) | 0.012 | 0.03 (−1.11, 0.18) | 0.680 | ||
| DBP (per mmHg) | 0.05 (−0.13, 0.23) | 0.576 | −0.03 (−0.10, 0.02) | 0.213 | ||||
| Lipid-lowering agent | 36.5 (4.81, 68.3) | 0.024 | −1.8 (−12.5, 8.7) | 0.729 | ||||
| HD vintage (per month) | −0.35 (−0.52, −0.18) | <0.001 | −0.18 (−0.34, −0.01) | 0.029 | −0.03 (−0.09, 0.02) | 0.240 | −0.78 (−0.13, −0.01) | 0.010 |
| AK (versus polysulfone) | ||||||||
| PMMA | 17.4 (−8.9, 43.9) | 0.195 | −0.93 (−9.79, 7.93) | 0.837 | ||||
| Cellulose citrate | −5.3 (−43.9, 33.2) | 0.786 | 8.16 (−4.74, 21.0) | 0.215 | ||||
| KT/V (per unit) | −87.4 (−149.7, −25.1) | 0.006 | −1.71 (−22.7, 19.3) | 0.873 | ||||
| Albumin (per g/dL) | 26.5 (−4.52, 57.5) | 0.094 | 33.5 (23.6, 43.5) | <0.001 | 27.6 (17.2, 38.0) | <0.001 | ||
| AST (per IU/L) | 0.23 (−0.26, 0.73) | 0.359 | −0.09 (−0.26, 0.07) | 0.257 | ||||
| ALT (per IU/L) | 0.21 (−0.16, 0.58) | 0.261 | −0.02 (−0.15, 0.09) | 0.678 | ||||
| Hemoglobin (per g/dL) | 8.37 (−0.87, 17.6) | 0.076 | 6.30 (3.25, 9.34) | <0.001 | 5.0 (1.98, 8.04) | 0.001 | ||
| T-bilirubin (per mg/dL) | −23.5 (−69.6, 22.5) | 0.315 | −16.0 (−31.4, −0.72) | 0.040 | ||||
| Ferritin (per μg/dL) | 0.006 (−0.01, 0.03) | 0.651 | −0.004 (−0.012, 0.005) | 0.373 | ||||
| Iron (per μg/dL) | 0.329 (−0.16, 0.82) | 0.190 | 0.28 (0.11, 0.44) | 0.001 | ||||
| TIBC (per μg/dL) | 0.86 (0.59, 1.12) | <0.001 | 0.70 (0.44, 0.97) | <0.001 | 0.21 (0.11, 0.30) | <0.001 | 0.10 (0.01, 0.19) | 0.028 |
| iPTH (per pg/mL) | −0.05 (−0.08, −0.01) | 0.008 | 0.005 (−0.008, 0.018) | 0.445 | ||||
| Alk-p (per mg/dL) | −0.11 (−0.27, 0.05) | 0.181 | −0.007 (−0.06, 0.04) | 0.788 | ||||
| Sodium (per meq/L) | −4.62 (−8.18, −1.05) | 0.011 | −3.77 (−7.04, −0.50) | 0.024 | 0.27 (−0.92, 1.47) | 0.650 | ||
| Potassium (per meq/L) | −6.05 (−23.5, 11.0) | 0.496 | 7.54 (1.74, 13.3) | 0.011 | ||||
| iCa (per mg/dL) | −0.50 (−22.6, 21.6) | 0.965 | 2.18 (−5.21, 9.58) | 0.562 | ||||
| Phosphate (per mg/dL) | −3.36 (−11.8, 5.12) | 0.436 | −14.0 (22.4, −5.6) | 0.001 | 3.15 (0.32, 5.98) | 0.029 | ||
| Uric acid (per mg/dL) | 17.9 (9.39, 26.5) | <0.001 | 16.2 (7.6, 24.8) | <0.001 | 4.85 (1.96, 7.75) | 0.001 | ||
1 β is the regression coefficient. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure, HD, hemodialysis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TIBC, total iron-binding capacity; iPTH, intact parathyroid hormone; Alk-p, alkaline phosphatase.