Table 2.
AMD genes involved in the inflammatory pathway.
| Gene | Locus | Function |
|---|---|---|
| IL-1 | 2q14 | Cytokine |
| IL-6 | 7p15.3 | Cytokine |
| IL-8 | 4q12-q13 | Chemokine |
| CCL3 | 17q11.2-q12 | Chemokine |
| CCL4 | 17q11.2-q12 | Chemokine |
| CCR3 | 3p21.3 | Chemokine receptor |
| CFH | 1q31 | Complement factor H |
| C2 | 6p21.33 | Complement component 2 |
| CFB | 6p21.33 | Complement factor B |
| C3 | 19p13.3-p13.2 | Complement component 3 |
| C9 | 5p13.1 | Complement component 9 |
| CFI | 4q25 | Complement factor 1 |
| ARMS2 | 10q26.16 | Possible activation of proinflammatory molecules |
| NLRP3 | 1q44 | Inflammasome |