Figure 1.

Spearman's correlation showing the time-dependent weight changes in the treatment groups and control. The nicotine and/or cadmium treatment caused a significant increase in average weight from P28 to P56 when compared with the control. It was observed that nicotine-cadmium treatment induced a decline in weight around P37 versus saline administered mice statistically. This is suggestive that the weight loss associated with tobacco use is not an exclusive effect of nicotine, but an effect of combined nicotine and cadmium in tobacco smoke.