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. Author manuscript; available in PMC: 2015 Dec 7.
Published in final edited form as: Lab Chip. 2014 Sep 25;14(23):4496–4505. doi: 10.1039/c4lc00785a

Figure 5.

Figure 5

Relationship of the degree of particle enrichment to the filtration fraction per gap, for high filtration ratio devices. Four 125µm-deep CIF devices with values of fgap ranging 2.2–10.0×10−4 were tested for their ability to enrich beads of various sizes (nominal diameter 4, 6, 8 and 10µm) present within a heterogeneous mixture. For all devices, the width of central channel was 100µm and the width of side channel final was 450µm, equivalent to a theoretical 24.4× enrichment of particles in the central channel (relative to the input). (A) The device with fgap = 2.2×10−4 was able to produce 8.6× enrichment for 4µm beads, 17.7× for 6µm beads, 22.2× for 8µm beads, and 24.1× for 10µm beads. (B) The device with fgap = 3.5×10−4 produced 2.3× enrichment for 4µm beads, 16.9× for 6µm beads, 22.6× for 8µm beads, and 24.2× for 10µm beads. (C) The device with fgap = 6.0×10−4 could no longer enrich 4µm beads, but was able to produce 2.3× enrichment for 6µm beads, 19.3× for 8µm beads, and 22.7× for 10µm beads. (D) The device with fgap = 10.0×10−4 could only produce enrichment of 12.0× for the largest 10µm beads.