Fig. 3.

Alignment of PARP14 homologs covering macro domain 1 and macro domain 2 (human residues 800–1200). Red boxes indicate sites that have been identified to be evolving under positive selection. Green blocks indicate sites for substrate binding and cyan blocks indicate macro domain 1 and 2 interacting sites [62]. Site 903 has nonpolar interactions with sites 1105 and 1143. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)