Table 3.

Amino acid changing mutations of human NAD metabolic enzymes currently segregating at high frequency (> 20%) in the human population. Evolutionary rare changes based on negative PAM250 scores are in bold.

Enzyme	Amino acid change (position)	Frequency
NRK	V ↔ M (358)	0.31
NADK	N ↔ K (262)	0.28
NT5E	T ↔ A (376)	0.76
PNP	G ↔ S (51)	0.22
ART1	L ↔ P (257)	0.55
ART3	S ↔ L (341)	0.47
ART4	D ↔ N (265)	0.28
PARP13	H ↔ Q (565)	0.26
	R ↔ K (485)	0.25
PARP15	G ↔ R (628)	0.23
PARP4	A ↔ P (1656)	0.42
	P ↔ T (1328)	0.38
	G ↔ R (1280)	0.38
	G ↔ A (1265)	0.38
	V ↔ A (1065)	0.64
	A ↔ T (899)	0.66
	S ↔ N (873)	0.23
PARP9	Y ↔ C (528)	0.54
PARP10	V ↔ A (630)	0.54
	L ↔ P (395)	0.35
	I ↔ V (249)	0.38