Table III.
Genotype and allele frequencies of IL10 gene polymorphisms
|
Genotypes
|
Alleles (frequency)(mean±SD)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IL10-592C/A | CC | CA | AA | C | A | |||||
| Patients | 30 (69) | 33 (69) | 6 (69) | 0.673 ± 0.02 | 0.326 ± 0.02 | |||||
| Control | 35 (64) | 26 (64) | 3 (64) | 0.750 ± 0.02 | 0.250 ± 0.02 | |||||
| P | 0.22 | 0.48 | 0.49 | 0.26 | 0.28 | |||||
| OR (CI) | 0.637 (0.321-1.264) | 1.33 (0.674-2.66) | 1.93 (0.463-8.0916) | 0.688 | 1.477 | |||||
| IL10-819C/T | CC | CT | TT | C | T | |||||
| Patients | 28 (69) | 37(69) | 4 (69) | 0.673±0.02 | 0.326 ± 0.02 | |||||
| Control | 43 (64) | 18(64) | 3 (64) | 0.812±0.02 | 0.187 ± 0.02 | |||||
| P | 0.003 | 0.0046 | 1.00 | 0.02 | 0.03 | |||||
| OR (CI) | 0.33 (0.16-0.67) | 2.95 (1.435-6.080) | 1.253 (0.269-5.820) | 1.25 | 2.09 | |||||
| IL10-1082A/G | AA | AG | GG | A | G | |||||
| Patients | 7(53) | 28 (53) | 18 (53) | 0.40 ± 0.02 | 0.60 ± 0.02 | |||||
| Control | 11(64) | 24(64) | 29 (64) | 0.36 ± 0.02 | 0.64 ± 0.02 | |||||
| P | 0.61 | 0.13 | 0.257 | 0.65 | 0.66 | |||||
| OR (CI) | 0.73 (0.26-2.04) | 1.86 (0.89-3.91) | 0.62 (0.29-1.31) | 1.18 | 0.84 | |||||
Statistically significant p<0.05; OR - odds ratio;CI - confidence interval