FIG. 1.

Pancreatic tumor histology in the setting of haploinsufficiency for either rpl23a or rpl36. Representative images of 7-month-old rpl23a^WT/WT; ptf1a:gal4-VP16; UAS:GFP-KRAS^G12V (A), rpl23a^hi2582/WT; ptf1a:gal4-VP16; UAS:GFP-KRAS^G12V (B), rpl36^WT/WT; ptf1a:gal4-VP16; UAS:GFP-KRAS^G12V (C) and rpl36^hi1807/WT; ptf1a:gal4-VP16; UAS:GFP-KRAS^G12V fish (D). For each genotype, upper left images depict fish with distended abdomen and transcutaneous eGFP fluorescence; upper right images depict excised abdominal viscera confirming eGFP+pancreatic tumors. Lower panels show representative histology of mixed acinar/ductal tumors. Insets confirm expression of GFP-KRAS^G12V fusion protein in malignant tumor epithelium as assessed by antibody staining for GFP (representative of n=96 tumors analyzed). Color images available online at www.liebertpub.com/zeb