FIG. 6.

Immunohistochemical analysis of zebrafish tumors reveals a significant reduction of rpl36 expression in KG^ptf1a;rpl36^hi1807/+ tumors compared with KG^ptf1a;rpl36^+/+ tumors. (A) IHC staining for rpl36 in a panel of tumor sections derived from either KG^ptf1a; rpl36^hi1807/+ or KG^ptf1a; rpl36^+/+ zebrafish (n=8 per group). (B) Quantification of staining intensity (1=light brown staining, 3=dark brown staining) in the tumor sections analyzed. Tumors occurring in fish with heterozygous loss of rpl36 displayed less intense labeling for rpl36. Color images available online at www.liebertpub.com/zeb