Table 1. Demographic and clinicopathological characteristics of non-small-cell lung cancer patients with defined EML4-ALK rearrangement and EGFR mutation status.

		EML4-ALK rearrangement			EGFR mutation
Characteristics	Total, N (%)	Positive	Negative	p	Positive	Negative	p
Patients, n	1160	94	1066		392	768
Age at diagnosis, years
Median	57	45	58	<0.001	57	57	0.597
Range	19–85	20–81	19–85		27–81	19–85
Gender, n
Female	454 (39.1)	40	414	0.479	212	242	<0.001
Male	706 (60.9)	54	652		180	526
Smoking status, n
Never smoking	626 (54.0)	64	562	0.005*	272	320	<0.001*
Smoking	525 (45.3)	30	495		118	441
Unknown	9 (0.8)	0	9		2	7
Pathology, n
Adenocarcinoma	906 (78.1)	81	825	0.036§	368	538	<0.001§
Squamous	168 (14.5)	9	159		12	156
Adenosquamous	22 (1.9)	2	20		9	13
Others	64 (5.5)	2	62		3	61
Differentiation, n
Moderate to high	434 (37.4)	31	403	0.649£	200	234	<0.001£
Poor	632 (54.5)	55	577		161	471
Undetermined	94 (8.1)	8	86		31	33
Stage, n
I–IIIA	661 (57.0)	41	620	0.007	212	449	0.154
IIIB–IV	499 (43.0)	53	446		180	319
Family history of cancer, n
Yes	238 (20.5)	22	216	0.470	79	159	0.826
No	922 (79.5)	72	850		313	609
Cough, n
Yes	856 (73.8)	68	788	0.738	300	488	0.139
No	304 (26.2)	26	278		92	186
Chest pain, n
Yes	504 (43.4)	39	465	0.690	181	323	0.181
No	656 (56.6)	55	601		211	445
Hemoptysis, n
Yes	258 (22.2)	14	244	0.077	93	165	0.867
No	902 (77.8)	80	822		299	603
Shortness of breath, n
Yes	336	20	316	0.089	121	215	0.308
No	824	74	750		271	553

*p values compare never smoking with smoking.

^§p values compare adenocarcinoma plus adenosquamous with squamous and others.

^£p values compare moderate to high differentiation with poor differentiation.

Bold fonts indicate significant p values.