Table 2. Odds ratio of EML4-ALK rearrangements in patients younger than 50.5 yrs versus patients older than 50.5 yrs, stratified by clinicopathological features.
| <50.5 years old | >50.5 years old | ||||||
|---|---|---|---|---|---|---|---|
| Characteristics | Patients with EML4-ALK rearrangements/total | Incidence, % | Patients with EML4-ALK rearrangements/total | Incidence, % | OR | 95% CI | p |
| Gender | |||||||
| Male | 35/186 | 18.8 | 19/520 | 3.7 | 6.1 | 3.4–11.0 | <0.001 |
| Female | 31/170 | 18.2 | 9/284 | 3.2 | 6.8 | 3.2–14.7 | <0.001 |
| Smoking status | |||||||
| Smoking | 21/123 | 17.1 | 9/402 | 2.2 | 9.0 | 4.0–20.2 | <0.001 |
| Non-smoking | 29/165 | 17.6 | 35/461 | 7.6 | 2.6 | 1.5–4.4 | <0.001 |
| Histological subtypes | |||||||
| Adenocarcinoma§ | 60/300 | 20.0 | 23/628 | 3.7 | 6.6 | 4.0–10.9 | <0.001 |
| Non-adenocarcinoma | 6/57 | 10.5 | 5/175 | 2.9 | 4.0 | 1.2–13.6 | 0.027 |
| Cancer stage | |||||||
| I–IIIA | 24/148 | 16.2 | 17/513 | 3.3 | 5.2 | 2.9–10.8 | <0.001 |
| IIIB–IV | 42/208 | 20.2 | 11/291 | 3.8 | 6.4 | 3.2–12.9 | <0.001 |
§Adenocarcinoma includes adenocarcinoma and adenosquamous carcinoma.
Abbreviations: OR, odds ratio; CI, confidence interval. Yrs, years old.