Development pattern of neural substrates of the triadic model. The PFC develops linearly with age, with typical adults possessing the most mature, efficient systems. The striatum and its related systems show a hyper-responsive peak in adolescence in positive contexts, but can also present reduced responsivity in conditions of various cognitive demands. Similarly, the amygdala-centered network has been shown to be hyper-responsive to threat in adolescents, but hyporesponsive in a reward context.