Table 1.

Functional in vitro nuclear hormone antagonist potency

	IC50 (µM)
Drug	MR	PR (EC50)	AR	GR	ER	Manufacturer	Reference
Cd-(R)14c	0.005	2.5	>10	>10	>10a	Pfizer	[13]
Progesterone	0.010	0.0002	NR	none	NR		[14]
Spironolactone	0.013	2.6	0.52	6.9	5.7	Generic	[15]
BAY-94-8862	0.018	>10	>10	>10	>10	Bayer	[16]
PF-03882845	0.021	>100	>10	>10	NR	Pfizer	[13,15]
BR-4628	0.028	9.0	4.4	5.5	NR	Bayer	[17]
Cd 13i	0.038	NR	>5	>5	>5	Merck	[18]
Eplerenone	0.122	>10	>10	NR	>10	Novartis	[13,15]
SM-368229	0.130	NR	5.0	30	NR	Dainippon Sumitomo	[19]

NR, either not reported or done using comparable methodology

^aIC₅₀ for receptor binding