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. 2014 Dec 1;6(9-9):77. doi: 10.1186/s13195-014-0077-y

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© Swirski et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Correlation between Aβ and soluble pSer129 α-syn. Each point represents a separate case. The best-fit linear regression (solid lines) and 95% confidence intervals (interrupted lines) are superimposed. Only significant P-values (and associated correlation coefficients) are shown in the figure. Significant negative correlations between soluble Aβ42 and soluble pSer129 α-syn were found in the cingulate (CG) cortex and thalamus (TH). In contrast, a significant positive correlation was found between soluble Aβ42 and soluble pSer129 α-syn in the midfrontal (MF) cortex. Significant negative correlations were found between soluble Aβ40 and soluble pSer129 α-syn in the CG, parahippocampal (PH) cortex and TH. Significant negative correlations were also found between soluble pSer129 α-syn and insoluble Aβ42 in the MF cortex and TH. A significant positive correlation was observed between soluble pSer129 α-syn and insoluble Aβ40 in the PH cortex. Aβ, amyloid-β; pSer129 α-syn, alpha-synuclein phosphorylated at serine 129.