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. 2014 Nov 18;14:276. doi: 10.1186/s12866-014-0276-5

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© Baloni et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Representation of the feasible pathways identified from transcriptomics and phenotypic analysis. (a) Selected metabolic pathways with enzymes vertically ordered from bottom to top. They are colored in grey scale based on the extent of normalized gene expression. Multiple boxes present in a single layer depict the alternate genes encoding similar enzymes. (b) Representative pathways with the level of gene expression in reference condition (c) Schematic illustrating alternate enzymes being highly expressed in glycolysis, highlighted in orange (d) Multiple sequence alignment of tpi (triose phosphate isomerase) for Mtb and two Msm proteins. Sequence identity and conservation along with catalytic site residues (*) are shown.