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Glucose-stimulated insulin secretion (GSIS). Insulinotropic effect of GSIS from isolated pancreatic islets in absence or presence of methylglyoxal. Insulin secretion was stimulated by increasing concentrations of glucose, as indicated below the x-axis. Bars represent the mean ± S.E.M. ∗ P < 0.01 compared with the respective control group; Ω P < 0.01 compared with 5.6 or 16.7 mM of glucose; # P < 0.01 compared with 5.6 or 8.3 mM of glucose.
