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. Author manuscript; available in PMC: 2015 May 20.
Published in final edited form as: Nature. 2014 Nov 10;515(7527):389–393. doi: 10.1038/nature13885

Figure 1. Development of a catalytic system to overcome fundamental limitations of heterocyclic C–H bond functionalizations.

Figure 1

a, Adverse effects of strong coordination between Pd(II) catalysts and heterocycles. b, Avoiding heterocycle poisoning via on-site generation of Pd(II) catalysts. c, Overriding the conventional positional selectivity directed by heterocycles.