Skip to main content
. Author manuscript; available in PMC: 2015 May 20.
Published in final edited form as: Nature. 2014 Nov 10;515(7527):389–393. doi: 10.1038/nature13885

Figure 4. Overriding the conventional positional selectivity dictated by heterocycles.

Figure 4

a, b, Reactions of substrates prone to heterocycle-directed cyclometalation. c, Lactam products formed via hydrogenation and removal of the t-butyl groups (yields over two steps are shown).